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When a mysterious toxin accidentally enters the water supply, one by one the townspeople fall victim to an uncontrollable urge for sadistic violence and horrific bloodshed. In an attempt to contain the epidemic, the military steps in, using deadly force to close off access into and out of town, but also abandoning the few healthy citizens to the escalating carnage. For Sheriff Dutton (Timothy Olyphant), his pregnant wife Judy (Radha Mitchell), medical assistant Becca (Danielle Panabaker) and deputy Russell (Joe Anderson), Ogden Marsh is now a bloody arena bordered by wheat fields and farms. Unable to trust former neighbors and friends, targeted by the authorities and terrified of contracting the illness themselves, they are forced to band together, in a desperate attempt to escape both their murderous neighbors — and their government captors.